Nanosphere to Release Q3 2009 Earnings Results and Hold Investor Call Thursday, November 5

Nanosphere, Inc., (Nasdaq:NSPH), which develops, manufactures, and markets advanced molecular diagnostics systems, will report its results for the third quarter of 2009 after market close on Thursday, November 5, 2009. The company will also hold a live investor conference call and webcast at 5:00 P.M., Eastern Time.

The teleconference can be accessed by dialing 888-713-4218 (U.S./Canada) or 617-213-4870 (international), participant code 68742213. The call will also be broadcast live over the Internet and can be accessed by interested parties at the Investor Relations tab on the Nanosphere website: www.nanosphere.us.

Participants may pre-register for the call at: https://www.theconferencingservice.com/prereg/key.process?key=PCA9ULWQT. Pre-registrants will be issued a pin number to use when dialing into the live call, which will provide quick access to the conference by bypassing the operator upon connection. For interested individuals unable to join the call or webcast, a replay will be available through November 11, 2009 by dialing 888-286-8010 or for international calls 617-801-6888, pass code 80886974, or on the company's website.

About Nanosphere, Inc.

Nanosphere develops, manufactures, and markets an advanced molecular diagnostics platform, the Verigene® System, for direct genomic and ultra-sensitive protein detection. This easy to use and cost effective platform enables simple, low cost and highly sensitive genomic and protein testing on a single platform. Nanosphere is based in Northbrook, IL. Additional information is available at http://www.nanosphere.us.