Key Challenges and Issues Facing the World Gene Amplification Technologies Market

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World Gene Amplification Technologies Market

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This report analyzes the worldwide markets for Gene Amplification Technologies in Millions of US$. The major product segments analyzed are Polymerase Chain Reaction, and Other Gene Amplification Technologies. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, and Rest of World. Annual forecasts are provided for each region for the period of 2000 through 2015. The report profiles 93 companies including many key and niche players worldwide such as Abbott Laboratories, Applied Biosystems, Becton, Dickinson and Company, bioMerieux, Bio-Rad Laboratories, Cepheid, QIAGEN N.V, Roche Diagnostics, Rubicon Genomics, and Takara Bio, Inc. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

GENE AMPLIFICATION TECHNOLOGIES MCP-1102 A GLOBAL STRATEGIC BUSINESS REPORT

CONTENTS

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations I-1 Disclaimers I-2 Data Interpretation & Reporting Level I-2 Quantitative Techniques & Analytics I-2 Product Definitions and Scope of Study I-3 Definitions I-3 Polymerase Chain Reaction I-3 Other Gene Amplification Technologies I-3

II. EXECUTIVE SUMMARY

1. Industry Overview II-1 PCR Dominates Amplification Technologies II-1 Miniaturization - The Next Big Focus II-1 Critical in Diagnostic Procedures II-1 Leading Players II-2

2. Technology Overview II-3 Definition of Gene Amplification II-3 Target vs. Signal Amplification II-3 Available Types of Gene Amplification Technologies II-3 Polymerase Chain Reaction II-3 Reagents and Equipment required for PCR II-4 Reaction Steps II-4 Denaturation II-4 Annealing II-4 Extension II-4 Detection of Amplified Product/DNA II-5 (Q&Q) PCR II-5 Reverse Transcriptase PCR (RT-PCR) II-5 Alternative Technologies to PCR II-6 OmniPlex II-6 Strand Displacement Amplification II-6 Ligase Chain Reaction II-7 LCR Involves a Cyclic Two-Step Reaction II-7 Gene Amplification Technology (GAT) II-7 Hybrid Capture II-7 Isothermal DNA Amplification Techniques II-7 Rolling circle Amplification in Diagnostics II-7 Ican Isothermal Gene Amplification Technology II-8 Other Amplification Technologies II-8 Signal Amplification Technology II-8 Transcription Mediated Amplification II-8 DNA cleavage-based signal amplification II-9 Ramification Amplification Method II-9

3. End Use Market Analysis II-10 Medical and Diagnostics II-10 Role of Amplification Technology in Diagnostics of Infectious Diseases II-10 Diagnosis of Infectious Diseases by PCR II-10 Detection of Antimicrobial Resistance II-11 PCR Based Nucleic Acid Amplification for Detection of Antimicrobial Agents II-11 Nucleic Acid Amplification Testing (NAT) II-11 Nucleic Acid Amplification Methods II-11 DNA Amplification Technology in the Diagnosis of Infectious Diseases II-12 Forensic and Paternity II-12 Food Safety II-12

4. Product Innovations/Launches II-13 Bio-Rad Launches New CFX96 PCR Detection System II-13 Roche Introduces Genome Sequencer FLX System II-13 QIAGEN Launches TopTaq DNA Polymerase II-13 Applied Biosystems Introduces TaqMan Array Human MicroRNA Panel II-13 Spartan Introduces Spartan DX II-14 Applied Biosystems Launches Forensic Tools II-14 Applied Biosystems Introduces StepOne Real-Time PCR System II-15 Sigma-Aldrich Unveils GenomePlex Tissue Whole Genome Amplification Kit II-15 QIAGEN Rolls Out Wide RNAi and SYBR® Green-based RT- PCR II-15 Applied Biosystems Launches 7500 Fast Real-Time PCR System II-15 Applied Biosystems Launches 9800 Fast PCR System II-16 7900HT Fast Real-Time PCR System from Applied Biosystems II-16 Enzo Life Sciences Introduces New Advanced Amplification Technology II-16 Applied Biosystems Unveils AmpFSTR® Yfiler™ PCR Amplification Kit II-16 Amersham Launches GenomiPhi II-17 Rubicon Genomics Launches GenomePlex WGA II-17 Agilent Introduces Amplification Kit II-17 Linden Introduces Snapshot mRNA II-17 Rubicon Launches OmniPlex™ II-18

5. Recent Industry Activity II-19 Hologic Acquires Third Wave Technologies II-19 BIOTECON Acquires Roche's Technology License II-19 QIAGEN Signs a Global Licensing Agreement with BioHelix II-19 BioTrove and Gene Express Receive NIH Grant for Innovative Bio-experimentation II-19 SuperArray Bioscience Inks License Agreement with Applied Biosystems II-20 Merck Capital Takes Over Minority Interest in High Throughput Genomics II-20 NuGEN Enters into a Service Agreement with ExonHit II-20 Qiagen Enters into License Agreements with Roche and Ortho- Clinical II-21 Agilent Takes Over Stratagene II-21 Eiken Chemical Inks Licensing Agreement with Meridian Bioscience II-21 Sigma-Aldrich Acquires JRH II-22 Sigma-Aldrich Snaps Up Proligo II-22 Beckman to Acquire Agencourt II-22 Roche Diagnostics and Applera Corporation Expand PCR Licensing Program II-22 Mount and Hamilton Receive Patent II-22 Invitrogen Bags License from Applied Biosystems II-22 OriGene to Access TrueClone II-22 Orchid BioSciences to Turn into Orchid Cellmark II-23 QIAGEN Purchases Assets of Molecular Staging II-23 Cepheid, Applied Biosystems and Celera Diagnostics Sign Patent License Agreement II-23 Abbott Enters into Agreement with BioGenex II-23 Roche Inks Licensing Agreement with Incyte Corp II-23 Rubicon Genomics Signs Licensing Agreement with Sigma-Aldrich II-24 BioMérieux Teams-up with Cepheid II-24 Molecular Staging Collaborates with Eli Lilly II-24 Pacific Biometrics Inc. Receives Gene Amplification Patent II-24 Rubicon Introduces Service for Genome Amplification II-24 Takara Obtains Patent for New Amplification Method II-24

6. Focus on Select Global Players II-25 Abbott Laboratories (US) II-25 Applied Biosystems (US) II-25 Becton, Dickinson and Company (US) II-25 bioMérieux (France) II-26 Bio-Rad Laboratories (US) II-26 Cepheid (US) II-26 QIAGEN N.V (The Netherlands) II-26 Roche Diagnostics (Switzerland) II-27 Rubicon Genomics (US) II-27 Takara Bio, Inc. II-27

7. Global Market Perspective II-28

Table 1: World Recent Past, Current & Future Market Analysis for Gene Amplification Technologies by Geographic Region - US, Canada, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-28

Table 2: World Long-term Projections for Gene Amplification Technologies by Geographic Region - US, Canada, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-29

Table 3: World 10-Year Perspective for Gene Amplification Technologies by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, and Rest of World Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-30

Table 4: World Recent Past, Current & Future Market Analysis for Polymerase Chain Reaction (PCR) by Geographic Region - US, Canada, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-31

Table 5: World Long-term Projections for Polymerase Chain Reaction (PCR) by Geographic Region - US, Canada, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-32

Table 6: World 10-Year Perspective for Polymerase Chain Reaction (PCR) by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, and Rest of World Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-33

Table 7: World Recent Past, Current & Future Market Analysis for Other Gene Amplification Technologies by Geographic Region - US, Canada, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-34

Table 8: World Long-term Projections for Other Gene Amplification Technologies by Geographic Region - US, Canada, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-35

Table 9: World 10-Year Perspective for Other Gene Amplification Technologies by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, and Rest of World Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-36

III. MARKET

1. The United States III-1 A.Market Analysis III-1 Product Launches III-1 Strategic Corporate Developments III-4 Key Players III-8 Abbott Laboratories III-8 Applied Biosystems III-9 Bio-Rad Laboratories III-9 Cepheid III-9 Rubicon Genomics III-9 B.Market Analytics III-10

Table 10: US Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-10

Table 11: US Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-11

Table 12: US 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012 III-11

2. Canada III-12 A.Market Analysis III-12 Strategic Corporate Developments III-12 B.Market Analytics III-13

Table 13: Canadian Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-13

Table 14: Canadian Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-14

Table 15: Canadian 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012 III-14

3. Japan III-15 A.Market Analysis III-15 Key Player III-15 Takara Bio, Inc. III-15 B.Market Analytics III-16

Table 16: Japanese Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-16

Table 17: Japanese Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-17

Table 18: Japanese 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012 III-17

4. Europe III-18 Market Analysis III-18

Table 19: European Recent Past, Current & Future Analysis for Gene Amplification Technologies by Geographic Region - France, Germany, UK, Italy, and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-18

Table 20: European Long-term Projections for Gene Amplification Technologies by Geographic Region - France, Germany, UK, Italy, and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-19

Table 21: European Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-19

Table 22: European Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-20

Table 23: European 10-Year Perspective for Gene Amplification Technologies by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany, UK, Italy, & Rest of Europe Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-21

Table 24: European 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012 III-21

4a. France III-22 A.Market Analysis III-22 Key Player III-22 bioMérieux III-22 B.Market Analytics III-23

Table 25: French Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-23

Table 26: French Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-24

Table 27: French 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012 III-24

4b. Germany III-25 Market Analysis III-25

Table 28: German Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-25

Table 29: German Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-26

Table 30: German 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012 III-26

4c. United Kingdom III-27 Market Analysis III-27

Table 31: UK Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-27

Table 32: UK Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-28

Table 33: UK 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012 III-28

4d. Italy III-29 Market Analysis III-29

Table 34: Italian Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-29

Table 35: Italian Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-30

Table 36: Italian 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012 III-30

4e. Rest of Europe III-31 A.Market Analysis III-31 Product Launches III-31 Strategic Corporate Development III-32 Key Players III-33 Roche Diagnostics (Switzerland) III-33 QIAGEN N.V (Netherlands) III-33 B.Market Analytics III-34

Table 37: Rest of Europe Market for Gene Amplification Technologies - Recent Past, Current & Future Market Analysis by Segment for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-34

Table 38: Rest of Europe Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-35

Table 39: Rest of Europe 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012 III-35

5. Rest of World III-36 A.Market Analysis III-36 Product Launch III-36 Strategic Corporate Developments III-36 B.Market Analytics III-37

Table 40: Rest of World Market for Gene Amplification Technologies - Recent Past, Current & Future Market Analysis by Segment for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-37

Table 41: Rest of World (*) Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-38

Table 42: Rest of World 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012 III-38

IV. COMPETITIVE LANDSCAPE

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